Preliminary Associations Between Childhood Neglect, MIF, and Cortisol: Potential Pathways to Long-Term Disease Risk

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dc.contributor.authorBick, J., Nguyen, V., Leng, L., Piecychna, M., Crowley, M. J., Bucala, R., ... & Grigorenko, E. L.
dc.date.accessioned2015-07-23T18:20:43Z
dc.date.available2015-07-23T18:20:43Z
dc.date.issued2015
dc.description.abstractThe study examined Hypothalamus Pituitary Adrenal (HPA) axis and inflammatory signaling in 206 youth with histories of prenatal drug exposure and self reported histories of maltreatment. Youth with histories of severe neglect showed elevated levels of cortisol, the end product of the HPA axis, in comparison to youth with lower or minimal levels of neglect. Histories of severe neglect also were associated with increased levels of Macrophage Migration Inhibitory Factor (MIF), a cytokine known to be intricately involved in HPA axis regulation. Salivary MIF levels also were positively associated with youth age and prenatal drug exposure. These MIF and cortisol alterations may signal pathophysiological disruptions in the neuro endocrine and immune systems, which may lead to trajectories of increased disease risk among vulnerable youth. Our findings also provide preliminary support for the validity and reliability of a noninvasive salivary assessment of MIF. (Author Abstract)en_US
dc.identifier.citationBick, J., Nguyen, V., Leng, L., Piecychna, M., Crowley, M. J., Bucala, R., ... & Grigorenko, E. L. (2015). Preliminary associations between childhood neglect, MIF, and cortisol: Potential pathways to longā€term disease risk. Developmental psychobiology, 57(1), 131-139.en_US
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337818/pdf/nihms-655789.pdf
dc.identifier.urihttp://hdl.handle.net/11212/2365
dc.language.isoenen_US
dc.publisherDevelopmental psychobiologyen_US
dc.subjectchild abuseen_US
dc.subjectneglecten_US
dc.subjectparentingen_US
dc.subjectlong term effectsen_US
dc.subjectresearchen_US
dc.titlePreliminary Associations Between Childhood Neglect, MIF, and Cortisol: Potential Pathways to Long-Term Disease Risken_US
dc.typeArticleen_US

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