Associations Between Early Life Stress and Gene Methylation in Children

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dc.contributor.authorRomens, S. E., McDonald, J., Svaren, J., & Pollak, S. D.
dc.date.accessioned2015-07-23T18:11:56Z
dc.date.available2015-07-23T18:11:56Z
dc.date.issued2015
dc.description.abstractChildren exposed to extreme stress are at heightened risk for developing mental and physical disorders. However, little is known about mechanisms underlying these associations in humans. An emerging insight is that children's social environments change gene expression, which contributes to biological vulnerabilities for behavioral problems. Epigenetic changes in the glucocorticoid receptor gene, a critical component of stress regulation, were examined in whole blood from 56 children aged 11–14 years. Children exposed to physical maltreatment had greater methylation within exon 1F in the NR3C1 promoter region of the gene compared to nonmaltreated children, including the putative NGFI-A (nerve growth factor) binding site. These results highlight molecular mechanisms linking childhood stress with biological changes that may lead to mental and physical disorders. (Author Abstract)en_US
dc.identifier.citationRomens, S. E., McDonald, J., Svaren, J., & Pollak, S. D. (2015). Associations between early life stress and gene methylation in children. Child development, 86(1), 303-309.en_US
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305348/pdf/cdev0086-0303.pdf
dc.identifier.urihttp://hdl.handle.net/11212/2362
dc.language.isoenen_US
dc.publisherChild developmenten_US
dc.subjectchild abuseen_US
dc.subjectgenetic effectsen_US
dc.subjectlong term effectsen_US
dc.subjectresearchen_US
dc.titleAssociations Between Early Life Stress and Gene Methylation in Childrenen_US
dc.typeArticleen_US

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