Serotonin transporter polymorphism (5HTTLPR), severe childhood abuse and depressive symptom trajectories in adulthood
| dc.contributor.author | Nguyen, T. B., Gunn, J. M., Potiriadis, M., Everall, I. P., & Bousman, C. A. | |
| dc.date.accessioned | 2015-11-02T15:46:08Z | |
| dc.date.available | 2015-11-02T15:46:08Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | Background: Cross-sectional studies suggest that the serotonin transporter promoter region polymorphism (5-HTT gene-linked polymorphic region, 5HTTLPR) moderates the relationship between childhood abuse and major depressive disorder. Aims: To examine whether the 5HTTLPR polymorphism moderates the effect childhood abuse has on 5-year depressive symptom severity trajectories in adulthood. Method: At 5-year follow-up, DNA from 333 adult primary care attendees was obtained and genotyped for the 5HTTLPR polymorphism. Linear mixed models were used to test for a genotype × childhood abuse interaction effect on 5-year depressive symptom severity trajectories. Results: After covariate adjustment, homozygous s allele carriers with a history of severe childhood abuse had significantly greater depressive symptom severity at baseline compared with those without a history of severe childhood abuse and this effect persisted throughout the 5-year period of observation. Conclusions: The 5HTTLPR s/s genotype robustly moderates the effects of severe childhood abuse on depressive symptom severity trajectories in adulthood. (Author Abstract) | en_US |
| dc.identifier.citation | Nguyen, T. B., Gunn, J. M., Potiriadis, M., Everall, I. P., & Bousman, C. A. (2015). Serotonin transporter polymorphism (5HTTLPR), severe childhood abuse and depressive symptom trajectories in adulthood. British Journal of Psychiatry Open, 1(1), 104-109. | en_US |
| dc.identifier.uri | http://bjpo.rcpsych.org/content/1/1/104.full-text.pdf | |
| dc.identifier.uri | http://hdl.handle.net/11212/2607 | |
| dc.language.iso | en | en_US |
| dc.publisher | British Journal of Psychiatry Open | en_US |
| dc.subject | child abuse | en_US |
| dc.subject | long term effects | en_US |
| dc.subject | International Resources | en_US |
| dc.subject | England | en_US |
| dc.subject | research | en_US |
| dc.title | Serotonin transporter polymorphism (5HTTLPR), severe childhood abuse and depressive symptom trajectories in adulthood | en_US |
| dc.type | Article | en_US |