Human Papillomavirus-type distribution in anogenital lesions of prepubertal children

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dc.contributor.authorBraun, S. A., Silling, S., Schloer, S. M., Hofmann, S. C., Fritzen, B., Oellig, F., ... & Kreuter, A.
dc.date.accessioned2015-09-28T18:53:58Z
dc.date.available2015-09-28T18:53:58Z
dc.date.issued2021
dc.description.abstractBackground In contrast to adults, only limited data are available on the human papillomavirus (HPV)-type spectrum in anogenital warts (AGW) of children. Objective This study aimed to evaluate the HPV-type spectrum in AGW of prepubertal children. Materials & methods In a retrospective German multicentre study, HPV genotyping was performed in AGW biopsies of 55 1- to 12-year-old children using HPV group-specific PCRs followed by hybridization with type-specific probes or sequence analysis. Results Human papillomavirus-DNA was found in 53 of the 55 AGW. In 58.5% (31/53) of the HPV-positive AGW, mucosal HPV types were detected. HPV6 (27/53, 50.9%) was the predominant type. 43.4% (23/53) of the lesions were induced by cutaneous HPV types (HPV2, HPV27, HPV57). Mucosal HPV types were significantly more common in children under 5 years of age than in children 5 years of age and older (22/25, 88.0% [95% CI: 70.0–95.8] vs. 9/28, 32.1% [95% CI: 17.9–50.7], P < 0.001). In contrast, cutaneous HPV types were significantly more prevalent in the 5- to 12-year age group (4/25, 16.0% [95% CI 6.4–34.7] vs. 19/28, 67.9% [95% CI 49.3–82.1], P < 0.001). Conclusion Anogenital warts in 5- to 12-year-old children are frequently associated with cutaneous HPV types, possibly due to horizontal transmission. HPV typing, in addition to comprehensive clinical and psychosocial evaluation, can potentially help in the assessment of these cases.en_US
dc.identifier.citationBraun, S. A., Silling, S., Schloer, S. M., Hofmann, S. C., Fritzen, B., Oellig, F., ... & Kreuter, A. (2021). Human Papillomavirus‐type distribution in anogenital lesions of prepubertal children. Journal of the European Academy of Dermatology and Venereology, 35(5), 1219-1225.en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jdv.17114
dc.identifier.urihttp://hdl.handle.net/11212/2522
dc.language.isoenen_US
dc.publisherJournal of the European Academy of Dermatology and Venereologyen_US
dc.subjectInternational Resourcesen_US
dc.subjectGermanyen_US
dc.subjectdiseaseen_US
dc.subjectmedical evaluation
dc.titleHuman Papillomavirus-type distribution in anogenital lesions of prepubertal childrenen_US
dc.typeen_US
dc.typeen_US
dc.typetexten_US

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