The Devastating Clinical Consequences of Child Abuse and Neglect: Increased Disease Vulnerability and Poor Treatment Response in Mood Disorders

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dc.contributor.authorLippard, E. T., & Nemeroff, C. B.
dc.date.accessioned2020-02-05T15:40:42Z
dc.date.available2020-02-05T15:40:42Z
dc.date.issued2020
dc.description.abstractA large body of evidence has demonstrated that exposure to childhood maltreatment at any stage of development can have long-lasting consequences. It is associated with a marked increase in risk for psychiatric and medical disorders. This review summarizes the literature investigating the effects of childhood maltreatment on disease vulnerability for mood disorders, specifically summarizing cross-sectional andmore recent longitudinal studies demonstrating that childhood maltreatment is more prevalent and is associated with increased risk for first mood episode, episode recurrence, greater comorbidities, and increased risk for suicidal ideation and attempts in individuals with mood disorders. It summarizes the persistent alterations associated with childhood maltreatment, including alterations in the hypothalamicpituitary-adrenal axis and inflammatory cytokines, which may contribute to disease vulnerability and a more pernicious disease course. The authors discuss several candidate genes and environmental factors (for example, substance use) that may alter disease vulnerability and illness course and neurobiological associations that may mediate these relationships following childhood maltreatment. Studies provide insight into modifiable mechanisms and provide direction to improve both treatment and prevention strategies.en_US
dc.identifier.citationLippard, E. T., & Nemeroff, C. B. (2020). The devastating clinical consequences of child abuse and neglect: increased disease vulnerability and poor treatment response in mood disorders. American journal of psychiatry, 177(1), 20-36.en_US
dc.identifier.urihttps://adaa.org/sites/default/files/Charles%20Nemeroff%20Jan%202020%20AJP%20Article.pdf
dc.identifier.urihttp://hdl.handle.net/11212/4587
dc.language.isoen_USen_US
dc.publisherAmerican journal of psychiatryen_US
dc.subjectchild abuseen_US
dc.subjectlong term effectsen_US
dc.subjectreviewen_US
dc.subjectmental health outcomesen_US
dc.subjecthealth effectsen_US
dc.titleThe Devastating Clinical Consequences of Child Abuse and Neglect: Increased Disease Vulnerability and Poor Treatment Response in Mood Disordersen_US
dc.typeArticleen_US

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