General and emotion-specific alterations to cognitive control in women with a history of childhood abuse
| dc.contributor.author | Seghete, Kristen L. Mackiewicz ; Kaiser, Roselind H. ; DePrince, Anne P. ; Banich, Marie T. | |
| dc.date.accessioned | 2019-02-06T18:22:57Z | |
| dc.date.available | 2019-02-06T18:22:57Z | |
| dc.date.issued | 2017 | |
| dc.description.abstract | Background: Although limited, the literature suggests alterations in activation of cognitive control regions in adults and adolescents with a history of childhood abuse. The current study examined whether such alterations are increased in the face of emotionally-distracting as compared to emotionally neutral information, and whether such alterations occur in brain regions that exert cognitive control in a more top-down sustained manner or a more bottom-up transient manner. Methods: Participants were young adult women (ages 23–30): one group with a history of childhood physical or sexual abuse (N = 15) and one with no trauma exposure (N = 17), as assessed through the Trauma History Questionnaire and a two-stage interview adapted from the National Crime Victims Survey. Participants underwent fMRI scanning while completing hybrid block/event-related versions of a classic color-word and an emotional Stroop paradigm (threat and positive words). This paradigm allowed us to examine both sustained (activation persisting across blocks) and transient (event-specific activation) aspects of cognitive control. Results: Women with a history of childhood abuse demonstrated decreased recruitment of frontal-parietal regions involved in cognitive control and enhanced recruitment of a ventral attention surveillance network during blocks of both versions of the Stroop task. Additionally, they had less suppression of brain regions involved in self-referential processes for threat blocks, but greater suppression of these regions for positive blocks. Severity of avoidance symptoms was associated with sustained activation in lateral prefrontal regions, whereas hyperarousal/re-experiencing symptoms were associated with sustained activity in temporal regions. No differential effects were observed for transient control. Conclusions: Results suggest exposure to childhood abuse is associated with blunted recruitment of brain regions supporting task-set maintenance but hypervigilance for task-irrelevant information, regardless of whether distractors are emotionally neutral or emotional. Exposure to childhood abuse is also associated with less suppression of default mode brain regions associated with self-referential processing in the face of irrelevant threat information, but heightened ability to suppress similar processing for irrelevant positive information. (Author Abstract) | en_US |
| dc.identifier.citation | Seghete, Kristen L. Mackiewicz ; Kaiser, Roselind H. ; DePrince, Anne P. ; Banich, Marie T. (2017). General and emotion-specific alterations to cognitive control in women with a history of childhood abuse. Neuroimage: Clinical, 16, 151-164. | en_US |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S2213158217301614/pdfft?md5=a1dd3025ff607209549ed4ba0ab18c37&pid=1-s2.0-S2213158217301614-main.pdf | |
| dc.identifier.uri | http://hdl.handle.net/11212/4241 | |
| dc.language.iso | en | en_US |
| dc.publisher | Neuroimage: Clinical | en_US |
| dc.subject | child abuse | en_US |
| dc.subject | long term effects | en_US |
| dc.subject | psy | en_US |
| dc.subject | Adverse Childhood Experiences (ACE) | en_US |
| dc.subject | research | en_US |
| dc.title | General and emotion-specific alterations to cognitive control in women with a history of childhood abuse | en_US |
| dc.type | Article | en_US |