Child Abuse and Neglect, MAOA, and Mental Health Outcomes: A Prospective Examination

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dc.contributor.authorNikulina, V., Widom, C. S., & Brzustowicz, L. M.
dc.date.accessioned2014-07-14T15:42:45Z
dc.date.available2014-07-14T15:42:45Z
dc.date.issued2012
dc.description.abstractStudies have examined the interaction of MAOA genotype with childhood maltreatment in relation to depressive symptomatology and alcohol abuse with conflicting findings. Both high and low activity allele combinations have been shown to be protective for maltreated children with direction of findings varying by study methodology and participant’s sex. Methods: Participants in a prospective cohort design study involving court substantiated cases of child abuse and neglect and a matched comparison group were followed up into adulthood and interviewed (N = 802). Eighty-two percent consented to provide blood, 631 gave permission for DNA extraction and analyses, and 575 were included in the final sample. This sample included male, female, White, and Non-White (primarily Black) participants. Symptoms of dysthymia, major depression and alcohol abuse were assessed using the NIMH Diagnostic Interview Schedule-III-R. Results: Significant three-way interactions, MAOA genotype by abuse by sex, predicted dysthymic symptoms. Low-activity MAOA genotype buffered against symptoms of dysthymia in physically abused and multiply maltreated women. Significant three-way interactions, MAOA genotype by sexual abuse by race, predicted all outcomes. Low-activity MAOA genotype buffered against symptoms of dysthymia, major depressive disorder and alcohol abuse for sexually abused White participants. The high-activity genotype was protective in the Non-White sexually abused group. Conclusions: This prospective study provides evidence that MAOA interacts with child maltreatment to predict mental health outcomes. Reasons for sex differences and race findings are discussed. (Author Abstract)en_US
dc.identifier.citationNikulina, V., Widom, C. S., & Brzustowicz, L. M. (2012). Child Abuse and Neglect,MAOA, and Mental Health Outcomes: A Prospective Examination. Biological psychiatry, 71(4), 350-357.en_US
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295575/pdf/nihms326965.pdf
dc.identifier.urihttp://hdl.handle.net/11212/1572
dc.language.isoen_USen_US
dc.publisherBiological psychiatryen_US
dc.subjectchild abuseen_US
dc.subjectneglecten_US
dc.subjectphysical abuseen_US
dc.subjectMAOA genotypeen_US
dc.subjectdepressionen_US
dc.subjectdysthymiaen_US
dc.subjectalcohol abuseen_US
dc.subjectraceen_US
dc.subjectgenderen_US
dc.subjectprospective longitudinal designen_US
dc.subjectresearchen_US
dc.subjectlong term effectsen_US
dc.titleChild Abuse and Neglect, MAOA, and Mental Health Outcomes: A Prospective Examinationen_US
dc.typeArticleen_US

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