Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function

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dc.contributor.authorAnacker, C., O'Donnell, K. J., & Meaney, M. J.
dc.date.accessioned2015-07-29T15:42:22Z
dc.date.available2015-07-29T15:42:22Z
dc.date.issued2014
dc.description.abstractWe review studies with human and nonhuman species that examine the hypothesis that epigenetic mechanisms, particularly those affecting the expression of genes implicated in stress responses, mediate the association between early childhood adversity and later risk of depression. The resulting studies provide evidence consistent with the idea that social adversity, particularly that involving parent-offspring interactions, alters the epigenetic state and expression of a wide range of genes, the products of which regulate hypothalamic-pituitary-adrenal function. We also address the challenges for future studies, including that of the translation of epigenetic studies towards improvements in treatments. (Author Abstract)en_US
dc.identifier.citationAnacker, C., O'Donnell, K. J., & Meaney, M. J. (2014). Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function. Dialogues in clinical neuroscience, 16(3), 321-333.en_US
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214175/pdf/DialoguesClinNeurosci-16-321.pdf
dc.identifier.urihttp://hdl.handle.net/11212/2397
dc.language.isoenen_US
dc.publisherDialogues in clinical neuroscienceen_US
dc.subjectchild abuseen_US
dc.subjectAdverse Childhood Experiences (ACE)en_US
dc.subjecttraumaen_US
dc.subjectparentingen_US
dc.subjectliterature reviewen_US
dc.titleEarly life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal functionen_US
dc.typeArticleen_US

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