Borderline personality disorder and childhood trauma: Exploring the affected biological systems and mechanisms

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dc.contributor.authorCattane, N., Rossi, R., Lanfredi, M., & Cattaneo, A.
dc.date.accessioned2017-07-06T18:23:15Z
dc.date.available2017-07-06T18:23:15Z
dc.date.issued2017
dc.description.abstractBackground: According to several studies, the onset of the Borderline Personality Disorder (BPD) depends on the combination between genetic and environmental factors (GxE), in particular between biological vulnerabilities and the exposure to traumatic experiences during childhood. We have searched for studies reporting possible alterations in several biological processes and brain morphological features in relation to childhood trauma experiences and to BPD. We have also looked for epigenetic mechanisms as they could be mediators of the effects of childhood trauma in BPD vulnerability. Discussion: We prove the role of alterations in Hypothalamic-Pituitary-Adrenal (HPA) axis, in neurotrasmission, in the endogenous opioid system and in neuroplasticity in the childhood trauma-associated vulnerability to develop BPD; we also confirm the presence of morphological changes in several BPD brain areas and in particular in those involved in stress response. Summary: Not so many studies are available on epigenetic changes in BPD patients, although these mechanisms are widely investigated in relation to stress-related disorders. A better comprehension of the biological and epigenetic mechanisms, affected by childhood trauma and altered in BPD patients, could allow to identify “at high risk” subjects and to prevent or minimize the development of the disease later in life.en_US
dc.identifier.citationCattane, N., Rossi, R., Lanfredi, M., & Cattaneo, A. (2017). Borderline personality disorder and childhood trauma: Exploring the affected biological systems and mechanisms. BMC Psychiatry, 17, 221.en_US
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472954/pdf/12888_2017_Article_1383.pdf
dc.identifier.urihttp://hdl.handle.net/11212/3419
dc.language.isoenen_US
dc.publisherBMC Psychiatryen_US
dc.subjectBorderline personality disorderen_US
dc.subjectlong term effectsen_US
dc.subjectchildhood traumaen_US
dc.subjectHPA axisen_US
dc.subjectEndogenous opioid systemen_US
dc.subjectNeurotransmissionen_US
dc.subjectNeuroplasticityen_US
dc.subjectNeuroimaging studiesen_US
dc.subjectEpigenetic mechanismsen_US
dc.titleBorderline personality disorder and childhood trauma: Exploring the affected biological systems and mechanismsen_US
dc.typeArticleen_US

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