The risk for major depression conferred by childhood maltreatment is multiplied by BDNF and SERT genetic vulnerability: a replication study

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dc.contributor.authorGutiérrez, B., Bellón, J. Á., Rivera, M., Molina, E., King, M., Marston, L., ... & Cervilla, J.
dc.date.accessioned2015-07-21T18:01:59Z
dc.date.available2015-07-21T18:01:59Z
dc.date.issued2015
dc.description.abstractBackground: There is limited evidence for a moderating role of both serotonin transporter (SERT) and brain-derived neurotrophic factor (BDNF) genes on the risk for major depression (MD) developing after childhood maltreatment. However, research on this topic remains inconclusive, and there is a lack of data from longitudinal studies with large and representative population samples. Our study aimed to clarify whether, in the presence of previous childhood maltreatment, individuals carrying low functional alleles for both SERT 5-HTTLPR and BDNF Val66Met polymorphisms had a higher risk for MD. Methods: We explored 2- and 3-way gene (SERT and BDNF) × environment (childhood maltreatment) interactions in a large sample of Spanish adults who were followed up over a 3-year period and assessed in person for both DSM-IV MD and exposure to childhood maltreatment. Results: Our study included 2679 participants. Those with both the 5-HTTLPR s allele and the BDNF Met allele showed the highest risk of MD if they had previously experienced emotional (z = 2.08, p = 0.037), sexual (z = 2.19, p = 0.029) or any kind of childhood abuse (z = 2.37, p = 0.018). These 3-way interactions remained significant regardless of whether the 5-HTTLPR triallelic or the 5-HTTLPR biallelic polymorphisms were included in the analyses. Limitations: Retrospective assessment of childhood maltreatment may have resulted in a moderate degree of recall bias. Conclusion: Our results confirm that the risk of depression conferred by childhood maltreatment is modified by variation at both SERT and BDNF genes. (Author Abstract)en_US
dc.identifier.citationGutiérrez, B., Bellón, J. Á., Rivera, M., Molina, E., King, M., Marston, L., ... & Cervilla, J. (2015). The risk for major depression conferred by childhood maltreatment is multiplied by BDNF and SERT genetic vulnerability: a replication study. Journal of psychiatry & neuroscience: JPN, 40(3), 187-196.en_US
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409436/pdf/jpn-40-187.pdf
dc.identifier.urihttp://hdl.handle.net/11212/2338
dc.language.isoenen_US
dc.publisherJournal of psychiatry & neuroscienceen_US
dc.subjectchild abuseen_US
dc.subjectrisk factorsen_US
dc.subjectresearchen_US
dc.titleThe risk for major depression conferred by childhood maltreatment is multiplied by BDNF and SERT genetic vulnerability: a replication studyen_US
dc.typeArticleen_US

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