Adverse Childhood Experiences are Associated with Detrimental Hemodynamics and Elevated Circulating Endothelin-1 in Adolescents and Young Adults RR

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dc.contributor.authorSu, S., Wang, X., Kapuku, G. K., Treiber, F. A., Pollock, D. M., Harshfield, G. A., ... & Pollock, J. S.
dc.date.accessioned2017-04-18T17:28:55Z
dc.date.available2017-04-18T17:28:55Z
dc.date.issued2014
dc.description.abstractGrowing evidence suggests that adverse childhood experiences (ACEs) increase the risks for coronary heart disease and hypertension in mid and late adulthood. We previously reported that early life stress induces a hyper-reactive endothelin (ET)-dependent cardiovascular phenotype in a rat model. In the present study, we evaluated whether exposure to ACEs is associated with greater peripheral resistance, arterial stiffness, blood pressure, or elevated circulating ET-1 levels in humans. In 221 healthy adolescents and young adults (mean age: 21; age range: 13–29), we found a graded association of ACE exposure with plasma ET-1 levels, of which on average 18% and 24% were higher in subjects with 1 ACE, and ≥2 ACEs compared to those with no ACEs (P=0.001). The subjects with moderate/severe exposure to ACEs (≥2 ACEs) had significantly higher total peripheral resistance index (+12%), diastolic blood pressure (+5%) and pulse wave velocity (+9%) compared with those who were not exposed. These associations were independent of age, race, gender, body mass index and childhood socioeconomic status. Our results indicate that early life stress promotes cardiovascular disease risk, specifically detrimental vascular and cardiac function, detectable in very young adulthood. (Author Abstract)en_US
dc.identifier.citationSu, S., Wang, X., Kapuku, G. K., Treiber, F. A., Pollock, D. M., Harshfield, G. A., ... & Pollock, J. S. (2014). Adverse Childhood Experiences Are Associated With Detrimental Hemodynamics and Elevated Circulating Endothelin-1 in Adolescents and Young Adults Novelty and Significance. Hypertension, 64(1), 201-207.en_US
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057352/pdf/nihms579519.pdf
dc.identifier.urihttp://hdl.handle.net/11212/3307
dc.language.isoen_USen_US
dc.publisherHypertensionen_US
dc.subjectchild abuseen_US
dc.subjectlong term effectsen_US
dc.subjectcardiovascular effectsen_US
dc.subjectphysiological effectsen_US
dc.subjectresearchen_US
dc.titleAdverse Childhood Experiences are Associated with Detrimental Hemodynamics and Elevated Circulating Endothelin-1 in Adolescents and Young Adults RRen_US
dc.typeArticleen_US

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