CALiO Search

Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma

Show simple item record

dc.contributor.author Jiang, S., Postovit, L., Cattaneo, A., Binder, E. B., & Aitchison, K. J.
dc.date.accessioned 2021-04-09T15:33:47Z
dc.date.available 2021-04-09T15:33:47Z
dc.date.issued 2019
dc.identifier.citation Jiang, S., Postovit, L., Cattaneo, A., Binder, E. B., & Aitchison, K. J. (2019). Epigenetic modifications in stress response genes associated with childhood trauma. Frontiers in psychiatry, 10, 808. en_US
dc.identifier.uri https://www.frontiersin.org/articles/10.3389/fpsyt.2019.00808/full
dc.identifier.uri http://hdl.handle.net/11212/5039
dc.description.abstract dverse childhood experiences (ACEs) may be referred to by other terms (e.g., early life adversity or stress and childhood trauma) and have a lifelong impact on mental and physical health. For example, childhood trauma has been associated with posttraumatic stress disorder (PTSD), anxiety, depression, bipolar disorder, diabetes, and cardiovascular disease. The heritability of ACE-related phenotypes such as PTSD, depression, and resilience is low to moderate, and, moreover, is very variable for a given phenotype, which implies that gene by environment interactions (such as through epigenetic modifications) may be involved in the onset of these phenotypes. Currently, there is increasing interest in the investigation of epigenetic contributions to ACE-induced differential health outcomes. Although there are a number of studies in this field, there are still research gaps. In this review, the basic concepts of epigenetic modifications (such as methylation) and the function of the hypothalamic-pituitary-adrenal (HPA) axis in the stress response are outlined. Examples of specific genes undergoing methylation in association with ACE-induced differential health outcomes are provided. Limitations in this field, e.g., uncertain clinical diagnosis, conceptual inconsistencies, and technical drawbacks, are reviewed, with suggestions for advances using new technologies and novel research directions. We thereby provide a platform on which the field of ACE-induced phenotypes in mental health may build. en_US
dc.language.iso en en_US
dc.publisher Frontiers in psychiatry en_US
dc.subject Adverse Childhood Experiences en_US
dc.subject research en_US
dc.subject childhood trauma en_US
dc.subject DNA en_US
dc.subject review en_US
dc.subject International Resources en_US
dc.subject Canada en_US
dc.title Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma en_US
dc.type Article en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

My Account