Keeshin, B. R., Strawn, J. R., Out, D., Granger, D. A., & Putnam, F. W.2017-08-282017-08-282015Keeshin, B. R., Strawn, J. R., Out, D., Granger, D. A., & Putnam, F. W. (2015). Elevated salivary alpha amylase in adolescent sexual abuse survivors with posttraumatic stress disorder symptoms. Journal of Child and Adolescent Psychopharmacology, 25(4), 344-350.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955591/pdf/cap.2014.0034.pdfhttp://hdl.handle.net/11212/3538Objective: Little is known regarding neuroendocrine responses in adolescent girls with posttraumatic stress disorder (PTSD) who have experienced sexual abuse. Therefore, we collected saliva samples three times daily for 3 days to assess concentrations of salivary alpha amylase (sAA) – a surrogate marker for autonomic nervous system (ANS) activity and, in particular, sympathetic activity – in sexually abused adolescent girls. Methods: Twenty-four girls (mean age: 15±1.4 years) who had experienced recent sexual abuse (i.e., sexual abuse occurred 1–6 months prior to study enrollment) and 12 healthy comparison subjects (mean age: 14.8±1.3 years) completed a structured interview and assessments to ascertain symptoms of posttraumatic stress, then collected saliva at home upon awakening, 30 minutes after waking, and at 5 p.m. on three consecutive school days. Results: For sexually abused girls, total PTSD symptoms were associated with higher overall morning levels of sAA (r[20]=0.51, p=0.02), a finding driven by intrusive symptoms (r[20]=0.43, p<0.05) and hyperarousal symptoms (r[20]=0.58, p=0.01). There were no significant differences in diurnal sAA secretion between the sexually abused girls and healthy comparison adolescents. Conclusions: Overall morning concentrations of sAA in sexually abused girls are associated with overall PTSD severity as well as symptoms of hyperarousal and intrusive symptoms, possibly reflecting symptom-linked increases in ANS tone. These data raise the possibility that alterations in ANS activity are related to the pathophysiology of sexual abuse-related PTSD in adolescent girls, and may inform therapeutic interventions (e.g., antiadrenergic medications). (Author Abstract)en-USPTSDneuroendocrine responsessexual abuseadolescentsArticle