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General and emotion-specific alterations to cognitive control in women with a history of childhood abuse

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dc.contributor.author Seghete, Kristen L. Mackiewicz ; Kaiser, Roselind H. ; DePrince, Anne P. ; Banich, Marie T.
dc.date.accessioned 2019-02-06T18:22:57Z
dc.date.available 2019-02-06T18:22:57Z
dc.date.issued 2017
dc.identifier.citation Seghete, Kristen L. Mackiewicz ; Kaiser, Roselind H. ; DePrince, Anne P. ; Banich, Marie T. (2017). General and emotion-specific alterations to cognitive control in women with a history of childhood abuse. Neuroimage: Clinical, 16, 151-164. en_US
dc.identifier.uri https://www.sciencedirect.com/science/article/pii/S2213158217301614/pdfft?md5=a1dd3025ff607209549ed4ba0ab18c37&pid=1-s2.0-S2213158217301614-main.pdf
dc.identifier.uri http://hdl.handle.net/11212/4241
dc.description.abstract Background: Although limited, the literature suggests alterations in activation of cognitive control regions in adults and adolescents with a history of childhood abuse. The current study examined whether such alterations are increased in the face of emotionally-distracting as compared to emotionally neutral information, and whether such alterations occur in brain regions that exert cognitive control in a more top-down sustained manner or a more bottom-up transient manner. Methods: Participants were young adult women (ages 23–30): one group with a history of childhood physical or sexual abuse (N = 15) and one with no trauma exposure (N = 17), as assessed through the Trauma History Questionnaire and a two-stage interview adapted from the National Crime Victims Survey. Participants underwent fMRI scanning while completing hybrid block/event-related versions of a classic color-word and an emotional Stroop paradigm (threat and positive words). This paradigm allowed us to examine both sustained (activation persisting across blocks) and transient (event-specific activation) aspects of cognitive control. Results: Women with a history of childhood abuse demonstrated decreased recruitment of frontal-parietal regions involved in cognitive control and enhanced recruitment of a ventral attention surveillance network during blocks of both versions of the Stroop task. Additionally, they had less suppression of brain regions involved in self-referential processes for threat blocks, but greater suppression of these regions for positive blocks. Severity of avoidance symptoms was associated with sustained activation in lateral prefrontal regions, whereas hyperarousal/re-experiencing symptoms were associated with sustained activity in temporal regions. No differential effects were observed for transient control. Conclusions: Results suggest exposure to childhood abuse is associated with blunted recruitment of brain regions supporting task-set maintenance but hypervigilance for task-irrelevant information, regardless of whether distractors are emotionally neutral or emotional. Exposure to childhood abuse is also associated with less suppression of default mode brain regions associated with self-referential processing in the face of irrelevant threat information, but heightened ability to suppress similar processing for irrelevant positive information. (Author Abstract) en_US
dc.language.iso en en_US
dc.publisher Neuroimage: Clinical en_US
dc.subject child abuse en_US
dc.subject long term effects en_US
dc.subject psy en_US
dc.subject Adverse Childhood Experiences (ACE) en_US
dc.subject research en_US
dc.title General and emotion-specific alterations to cognitive control in women with a history of childhood abuse en_US
dc.type Article en_US


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