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Childhood socioeconomic status and childhood maltreatment: Distinct associations with brain structure

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dc.contributor.author Lawson, G. M., Camins, J. S., Wisse, L., Wu, J., Duda, J. T., Cook, P. A., … Farah, M. J.
dc.date.accessioned 2017-05-10T18:06:43Z
dc.date.available 2017-05-10T18:06:43Z
dc.date.issued 2017
dc.identifier.citation Lawson, G. M., Camins, J. S., Wisse, L., Wu, J., Duda, J. T., Cook, P. A., … Farah, M. J. (2017). Childhood socioeconomic status and childhood maltreatment: Distinct associations with brain structure. PLoS ONE, 12(4), e0175690. en_US
dc.identifier.uri https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393603/pdf/pone.0175690.pdf
dc.identifier.uri http://hdl.handle.net/11212/3330
dc.description.abstract The present study examined the relationship between childhood socioeconomic status (SES), childhood maltreatment, and the volumes of the hippocampus and amygdala between the ages of 25 and 36 years. Previous work has linked both low SES and maltreatment with reduced hippocampal volume in childhood, an effect attributed to childhood stress. In 46 adult subjects, only childhood maltreatment, and not childhood SES, predicted hippocampal volume in regression analyses, with greater maltreatment associated with lower volume. Neither factor was related to amygdala volume. When current SES and recent interpersonal stressful events were also considered, recent interpersonal stressful events predicted smaller hippocampal volumes over and above childhood maltreatment. Finally, exploratory analyses revealed a significant sex by childhood SES interaction, with women’s childhood SES showing a significantly more positive relation (less negative) with hippocampus volume than men’s. The overall effect of childhood maltreatment but not SES, and the sex-specific effect of childhood SES, indicate that different forms of stressful childhood adversity affect brain development differently. en_US
dc.language.iso en en_US
dc.publisher PLoS One en_US
dc.subject childhood socioeconomic status en_US
dc.subject child abuse en_US
dc.subject cognitive development en_US
dc.subject brain development en_US
dc.title Childhood socioeconomic status and childhood maltreatment: Distinct associations with brain structure en_US
dc.type Article en_US


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