CALiO Search

The Levels of Cortisol and Oxidative Stress and DNA Damage in Child and Adolescent Victims of Sexual Abuse with or without Post-Traumatic Stress Disorder

Show simple item record

dc.contributor.author Şimşek, Ş., Yüksel, T., Kaplan, İ., Uysal, C., & Aktaş, H.
dc.date.accessioned 2016-12-09T18:28:17Z
dc.date.available 2016-12-09T18:28:17Z
dc.date.issued 2016
dc.identifier.citation Şimşek, Ş., Yüksel, T., Kaplan, İ., Uysal, C., & Aktaş, H. (2016). The Levels of Cortisol and Oxidative Stress and DNA Damage in Child and Adolescent Victims of Sexual Abuse with or without Post-Traumatic Stress Disorder. Psychiatry Investigation, 13(6), 616–621. en_US
dc.identifier.uri https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128349/pdf/pi-13-616.pdf
dc.identifier.uri http://hdl.handle.net/11212/3095
dc.description.abstract The aim of this study was to investigate whether cortisol and oxidative stress levels and DNA damage differ between individuals who developed PTSD or not following a sexual trauma. The study included 61 children aged between 5 and 17 years who sustained sexual abuse (M/F: 18/43). The patients were divided into two groups: patients with PTSD and patients without PTSD based, based on the results of a structured psychiatric interview (K-SADS-PL and CAPS-CA). Cortisol, glutathione peroxidase (GPx), superoxide dismutase (SOD), coenzyme Q, 8-Hydroxy-2-Deoxyguanosine (8-OHdG) were all evaluated by the ELISA method. Our evaluation revealed a diagnosis of PTSD in 51% (n=31) of victims. There was no significant difference between the groups with or without PTSD in terms of cortisol, GPx, SOD, coenzyme Q, and 8-OHdG levels. There was no correlation between CAPS scores and GPx, SOD, coenzyme Q, and 8-OHdG levels between patients with or without PTSD. In patients with PTSD, both cortisol and 8-OHdG levels decreased with increasing time after trauma, and there was no significant correlation with cortisol and 8-OHdG levels in patients without PTSD. Although the present study did not find any difference between the groups in terms of 8-OHdG concentrations, the decreases in both cortisol and 8-OHdG levels with increasing time after trauma is considered to indicate a relationship between cortisol and DNA damage. en_US
dc.language.iso en en_US
dc.publisher Psychiatry Investigation en_US
dc.subject cortisol en_US
dc.subject DNA damage en_US
dc.subject Oxidative stress en_US
dc.subject PTSD en_US
dc.subject trauma en_US
dc.subject International Resources en_US
dc.subject Turkey en_US
dc.title The Levels of Cortisol and Oxidative Stress and DNA Damage in Child and Adolescent Victims of Sexual Abuse with or without Post-Traumatic Stress Disorder en_US
dc.type Article en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

My Account