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Identifying methamphetamine exposure in children

Show simple item record Castaneto, M. S., Barnes, A. J., Scheidweiler, K. B., Schaffer, M., Rogers, K. K., Stewart, D., & Huestis, M. A. 2016-05-13T20:04:07Z 2016-05-13T20:04:07Z 2013
dc.identifier.citation Castaneto, M. S., Barnes, A. J., Scheidweiler, K. B., Schaffer, M., Rogers, K. K., Stewart, D., & Huestis, M. A. (2013). Identifying methamphetamine exposure in children. Therapeutic drug monitoring, 35(6). en_US
dc.description.abstract Methamphetamine (MAMP) use, distribution and manufacture remain a serious public health and safety problem in the United States, and children environmentally exposed to MAMP face a myriad of developmental, social and health risks, including severe abuse and neglect necessitating child protection involvement. It is recommended that drug-endangered children receive medical evaluation and care with documentation of overall physical and mental conditions and have urine drug testing.1 The primary aim of this study was to determine the best biological matrix to detect MAMP, amphetamine (AMP), methylenedioxymethamphetamine (MDMA), methylenedioxyamphetamine (MDA) and methylenedioxyethylamphetamine (MDEA) in environmentally exposed children. 91 children, environmentally exposed to household MAMP intake, were medically evaluated at the Child and Adolescent Abuse Resource and Evaluation (CAARE) Diagnostic and Treatment Center at the University of California, Davis (UCD) Children's Hospital. MAMP, AMP, MDMA, MDA and MDEA were quantified in urine and oral fluid (OF) by gas chromatography mass spectrometry (GCMS) and in hair by liquid chromatography tandem mass spectrometry (LCMSMS). Overall drug detection rates in OF, urine and hair were 6.9%, 22.1% and 77.8%, respectively. Seventy children (79%) tested positive for 1 or more drugs in 1 or more matrices. MAMP was the primary analyte detected in all 3 biological matrices. All positive OF (n=5) and 18 of 19 positive urine specimens also had a positive hair test. Hair analysis offered a more sensitive tool for identifying MAMP, AMP and MDMA environmental exposure in children than urine or OF testing. A negative urine, or hair test does not exclude the possibility of drug exposure, but hair testing provided the greatest sensitivity for identifying drug-exposed children. en_US
dc.language.iso en_US en_US
dc.publisher Therapeutic drug monitoring en_US
dc.subject methamphetamine en_US
dc.subject drug-endangered children en_US
dc.subject exposure en_US
dc.title Identifying methamphetamine exposure in children en_US
dc.type Article en_US

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