Human Papillomavirus-type distribution in anogenital lesions of prepubertal children
Date
2021
Journal Title
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Volume Title
Publisher
Journal of the European Academy of Dermatology and Venereology
Abstract
Background In contrast to adults, only limited data are available on the human papillomavirus (HPV)-type spectrum in
anogenital warts (AGW) of children.
Objective This study aimed to evaluate the HPV-type spectrum in AGW of prepubertal children.
Materials & methods In a retrospective German multicentre study, HPV genotyping was performed in AGW biopsies
of 55 1- to 12-year-old children using HPV group-specific PCRs followed by hybridization with type-specific probes or
sequence analysis.
Results Human papillomavirus-DNA was found in 53 of the 55 AGW. In 58.5% (31/53) of the HPV-positive AGW,
mucosal HPV types were detected. HPV6 (27/53, 50.9%) was the predominant type. 43.4% (23/53) of the lesions were
induced by cutaneous HPV types (HPV2, HPV27, HPV57). Mucosal HPV types were significantly more common in children under 5 years of age than in children 5 years of age and older (22/25, 88.0% [95% CI: 70.0–95.8] vs. 9/28, 32.1%
[95% CI: 17.9–50.7], P < 0.001). In contrast, cutaneous HPV types were significantly more prevalent in the 5- to 12-year
age group (4/25, 16.0% [95% CI 6.4–34.7] vs. 19/28, 67.9% [95% CI 49.3–82.1], P < 0.001).
Conclusion Anogenital warts in 5- to 12-year-old children are frequently associated with cutaneous HPV types, possibly due to horizontal transmission. HPV typing, in addition to comprehensive clinical and psychosocial evaluation, can
potentially help in the assessment of these cases.
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Keywords
International Resources, Germany, disease, medical evaluation
Citation
Braun, S. A., Silling, S., Schloer, S. M., Hofmann, S. C., Fritzen, B., Oellig, F., ... & Kreuter, A. (2021). Human Papillomavirus‐type distribution in anogenital lesions of prepubertal children. Journal of the European Academy of Dermatology and Venereology, 35(5), 1219-1225.