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Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function

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dc.contributor.author Anacker, C., O'Donnell, K. J., & Meaney, M. J.
dc.date.accessioned 2015-07-29T15:42:22Z
dc.date.available 2015-07-29T15:42:22Z
dc.date.issued 2014
dc.identifier.citation Anacker, C., O'Donnell, K. J., & Meaney, M. J. (2014). Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function. Dialogues in clinical neuroscience, 16(3), 321-333. en_US
dc.identifier.uri http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214175/pdf/DialoguesClinNeurosci-16-321.pdf
dc.identifier.uri http://hdl.handle.net/11212/2397
dc.description.abstract We review studies with human and nonhuman species that examine the hypothesis that epigenetic mechanisms, particularly those affecting the expression of genes implicated in stress responses, mediate the association between early childhood adversity and later risk of depression. The resulting studies provide evidence consistent with the idea that social adversity, particularly that involving parent-offspring interactions, alters the epigenetic state and expression of a wide range of genes, the products of which regulate hypothalamic-pituitary-adrenal function. We also address the challenges for future studies, including that of the translation of epigenetic studies towards improvements in treatments. (Author Abstract) en_US
dc.language.iso en en_US
dc.publisher Dialogues in clinical neuroscience en_US
dc.subject child abuse en_US
dc.subject Adverse Childhood Experiences (ACE) en_US
dc.subject trauma en_US
dc.subject parenting en_US
dc.subject literature review en_US
dc.title Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function en_US
dc.type Article en_US


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