CALiO Search

Preliminary Associations Between Childhood Neglect, MIF, and Cortisol: Potential Pathways to Long-Term Disease Risk

Show simple item record

dc.contributor.author Bick, J., Nguyen, V., Leng, L., Piecychna, M., Crowley, M. J., Bucala, R., ... & Grigorenko, E. L.
dc.date.accessioned 2015-07-23T18:20:43Z
dc.date.available 2015-07-23T18:20:43Z
dc.date.issued 2015
dc.identifier.citation Bick, J., Nguyen, V., Leng, L., Piecychna, M., Crowley, M. J., Bucala, R., ... & Grigorenko, E. L. (2015). Preliminary associations between childhood neglect, MIF, and cortisol: Potential pathways to long‐term disease risk. Developmental psychobiology, 57(1), 131-139. en_US
dc.identifier.uri http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337818/pdf/nihms-655789.pdf
dc.identifier.uri http://hdl.handle.net/11212/2365
dc.description.abstract The study examined Hypothalamus Pituitary Adrenal (HPA) axis and inflammatory signaling in 206 youth with histories of prenatal drug exposure and self reported histories of maltreatment. Youth with histories of severe neglect showed elevated levels of cortisol, the end product of the HPA axis, in comparison to youth with lower or minimal levels of neglect. Histories of severe neglect also were associated with increased levels of Macrophage Migration Inhibitory Factor (MIF), a cytokine known to be intricately involved in HPA axis regulation. Salivary MIF levels also were positively associated with youth age and prenatal drug exposure. These MIF and cortisol alterations may signal pathophysiological disruptions in the neuro endocrine and immune systems, which may lead to trajectories of increased disease risk among vulnerable youth. Our findings also provide preliminary support for the validity and reliability of a noninvasive salivary assessment of MIF. (Author Abstract) en_US
dc.language.iso en en_US
dc.publisher Developmental psychobiology en_US
dc.subject child abuse en_US
dc.subject neglect en_US
dc.subject parenting en_US
dc.subject long term effects en_US
dc.subject research en_US
dc.title Preliminary Associations Between Childhood Neglect, MIF, and Cortisol: Potential Pathways to Long-Term Disease Risk en_US
dc.type Article en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

My Account